Table of Contents
Organic Chemistry International
Volume 2014 (2014), Article ID 297586, 7 pages
Research Article

Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins

1P.G. Department of Chemistry, Central College Campus, Bangalore University, Bangalore, Karnataka 560 001, India
2Department of Pharmacology, K.L.E. University’s College of Pharmacy, Belgaum, Karnataka 590 010, India

Received 27 November 2013; Accepted 27 January 2014; Published 27 March 2014

Academic Editor: Vito Ferro

Copyright © 2014 Puttaraju Boregowda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Various 4-bromomethylcoumarins (1a-k) were reacted with methyl salicylate to yield 2-(2-oxo-2H-chromen-4-ylmethoxy)-benzoic acid methyl esters (2a-k). Formations of (3a-k) were achieved by using DBU under microwave irradiation. Structures of all the compounds were established on the basis of their spectral data. All the compounds were tested in vitro for their antimicrobial activity and cell cytotoxicity. All the tested compounds (2b-k) and (3a-k) were shown to be better activity against Staphylococcus aureus than the standard Ciprofloxacin. The compound (3k) (R = 6-OMe) was found to be more potent cytotoxic than the standard 5-fluorouracil.