Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins

Table 1

Results of antimicrobial activities of the synthesized compounds (2b–k) and (3a–k) MICs (μg/mL).

Compounds		Gram-positive			Gram-negative			Fungi
Number	R	S. aureus	E. faecalis	S. mutans	E. coli	K. pneumonia	P. aeruginosa	C. albicans	A. fumigatus
2b	7-CH3	0.4	50	0.2	6.25	100	6.25	12.5	0.4
2c	6-Cl	0.4	1.6	0.2	0.2	50	3.12	12.5	0.4
2d	6-Br	0.8	25	0.4	1.6	100	3.12	12.5	0.4
2e	6-F	0.4	3.12	0.2	1.6	100	6.25	>100	0.8
2f	5,6-benzo	0.4	50	0.2	6.25	100	6.25	12.5	0.4
2g	6,8-dimethyl	1.6	0.8	0.8	3.12	100	50	100	1.6
2h	6-isopropyl	0.8	6.25	0.4	0.4	100	25	12.5	0.4
2i	6-tert-butyl	0.8	6.25	0.8	0.2	100	25	12.5	0.2
2j	6-benzyl	0.8	12.5	0.4	1.6	100	6.25	100	0.8
2k	6-OMe	0.8	3.12	0.8	3.12	100	100	100	0.8
3a	6-CH3	0.2	0.2	0.2	50	100	50	12.5	—
3b	7-CH3	0.2	0.2	0.2	100	50	>100	0.2	—
3c	6-Cl	0.2	0.4	0.2	100	100	25	3.12	—
3d	6-Br	—	—	—	—	—	—	—	—
3e	6-F	0.2	0.4	0.4	100	100	>100	0.2	—
3f	5,6-benzo	0.2	0.4	3.12	50	100	0.2	0.2	—
3g	6,8-dimethyl	0.2	0.4	0.2	100	100	50	0.2	—
3h	6-isopropyl	0.2	0.4	0.2	50	100	3.12	0.2	—
3i	6-tert-butyl	0.2	0.8	0.2	50	>100	6.25	0.2	—
3j	6-benzyl	0.2	0.8	0.2	100	100	50	0.2	—
3k	6-OMe	0.2	0.4	3.12	50	100	6.25	0.2	—
Ciprofloxacin		2	2	2	1	1	4	—	—
Fluconazole		—	—	—	—	—	—	16	8