Synthesis and Biological Evaluation of 4-(3-Hydroxy-benzofuran-2-yl)coumarins

Table 2

Results of in  vitro cytotoxicity of the synthesized compounds (2b–k) and (3a–k) against Dalton’s Ascitic Lymphoma cell (1×10⁵) at the concentration of 100 μg/mL.

Number of compounds	R	Number of cells		% of dead cells
		Live	Dead
2b	7-CH3	49	51	51
2c	6-Cl	41	59	59
2d	6-Br	19	81	81
2e	6-F	42	58	58
2f	5,6-benzo	75	25	25
2g	6,8-dimethyl	55	45	45
2h	6-isopropyl	12	88	88
2i	6-tert-butyl	16	84	84
2j	6-benzyl	13	87	87
2k	6-OMe	18	82	82
3a	6-CH3	21	79	79
3b	7-CH3	56	44	44
3c	6-Cl	15	85	85
3d	6-Br	—	—	—
3e	6-F	34	66	66
3f	5,6-benzo	13	87	87
3g	6,8-dimethyl	21	79	79
3h	6-isopropyl	26	74	74
3i	6-tert-butyl	15	85	85
3j	6-benzyl	53	47	47
3k	6-OMe	11	89	89
5-Fluorouracil	—	12	88	88