Table of Contents
Organic Chemistry International
Volume 2014, Article ID 617153, 4 pages
Research Article

An Efficient Method for Synthesis of N-tert-Butyl Amides Using Oxalic Acid Dihydrate in Solvent-Free Condition

1Department of Chemistry, Rasht Branch, Islamic Azad University, P.O. Box 41325-3516, Rasht, Iran
2Department of Chemistry, Science and Research Amol Branch, Islamic Azad University, P.O. Box 678, Amol, Iran

Received 7 January 2014; Revised 17 February 2014; Accepted 21 March 2014; Published 8 April 2014

Academic Editor: Ashraf Aly Shehata

Copyright © 2014 Masoud Mokhtary and Seyedeh Khadijeh Nasernezhad. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient method for the synthesis of N-tert-butyl amides by reaction of nitriles with tert-butyl acetate or tert-butanol is described using oxalic acid dihydrate in solvent-free condition. The result showed that tert-butyl acetate served as a relatively better source of tert-butyl carbocation than tert-butanol.