Synthesis of Ibuprofen Using Silica-Supported Preyssler Nanoparticles as an Eco-Friendly, Inexpensive, and Efficient Catalyst

Table 1

Synthesis of Ibuprofen (6) in the presence of various heteropolyacids catalysts at room temperature conditions.

Entry	Catalyst	aYield (%)
1	H14[NaP5W30O110]/SiO2, (SPNPs)	97
2	H14[NaP5W30O110]	91
3	H14[NaP5W30O110]/SiO2 (50%)	81
4	H3[PW12O40]/SiO2 (50%)	67
5	H14[NaP5W29MoO110]	88
6	H3[PMo12O40]	62
7	H3[PW12O40]	72.5
8	H4[SiW12O40]	64
9	H4[SiMo12O40]	51
10	H6[P2W18O62]	86
11	H2SO4	59
12	Free	9
13	𝑝-TSA	63
14	Zeolite	68

aIsolated yield and were analyzed by GC.