Research Article
Synthesis and Antiproliferative Activity of Some Quinoline and Oxadiazole Derivatives
Table 1
LC50, TGI, and GI50 of quinoline analogues (5a–j) against HeLa and MDA-MB-435 cancer cell lines.
| | Compound | Drug concentrations calculated from graph (μM) | | Human cervix cancer cell line HeLa | Melanoma MDA-MB-435 | | LC50 | TGI | GI50 | LC50 | TGI | GI50 |
| | 5a | >100 | >100 | 87.0 | >100 | >100 | >100 | | 5b | >100 | >100 | 80.6 | >100 | >100 | >100 | | 5c | >100 | >100 | 73.20 | >100 | >100 | >100 | | 5d | >100 | 97.28 | 58.9 | >100 | 97.28 | >100 | | 5e | >100 | 88.17 | 50.6 | >100 | 88.17 | >100 | | 5f | >100 | >100 | 59.9 | >100 | >100 | >100 | | 5g | >100 | >100 | 93.0 | >100 | >100 | >100 | | 5 h | >100 | >100 | 62.7 | >100 | >100 | >100 | | 5i | >100 | >100 | >100 | >100 | >100 | >100 | | 5j | 91.33 | 63.19 | 35.1 | >100 | >100 | 60.4 | | ADR | 54.42 | <0.1 | <0.1 | 70.6 | 1.7 | <0.1 |
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ADR = adriamycin, positive control compound.
GI50 value of ≤1 M (i.e., 1 μmolar) is considered to demonstrate activity.
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