Impact of the COVID-19 Pandemic on Children and Adolescents with New-Onset Type 1 Diabetes

Figure 2

Schematic overview of suggested increased progression from presymptomatic islet autoimmunity to clinically manifest type 1 diabetes during the COVID-19 pandemic. Individuals with black border: no islet autoimmunity. Individuals with red border without filling: existing presymptomatic islet autoimmunity (also defined as stage 1 type 1 diabetes). Individuals with red filling: clinically overt type 1 diabetes (also defined as stage 3 type 1 diabetes). Please note that this is a simplified schematic representation. The frequencies of new cases of type 1 diabetes (red individuals) shown are not synonymous with the actual changes observed but are only meant to illustrate this.