Table of Contents
Physiology Journal
Volume 2013, Article ID 539076, 6 pages
Clinical Study

Combined Lung Transfer of NO and CO in Patients Receiving Methotrexate or Bleomycin Therapy Compared to Normal Subjects

1Pulmonary Function Testing Department, Lyon University Hospital, 165 Chemin du Grand-Revoyet, 69 495 Pierre-Bénite Cedex, France
2UCBL1 FRE CNRS 3310, 7 Passage du Vercors, 69367 Lyon Cedex, France
3Respiratory Diseases Department, Lyon University Hospital, 165 Chemin du Grand-Revoyet, 69495 Pierre-Bénite Cedex, France
4Lyon Sud-Charles Mérieux Medical Faculty, Claude Bernard Lyon 1 University, 69600 Oullins, France

Received 11 October 2012; Revised 26 November 2012; Accepted 24 December 2012

Academic Editor: Vincent Pialoux

Copyright © 2013 Chantal Viart-Ferber et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The first aim of the study is to determine whether combined lung diffusing capacities of nitric oxide (TLNO) and of carbon monoxide (TLCO) are accurate in the followup of patients receiving either methotrexate (MTX) or bleomycin (BLM). The second objective is to determine whether TLCO, TLNO, KCO, and TLCO/VI% (inspiratory volume expressed as percentage of predicted value) correlate better with the diffusing capacity of the membrane (Dm) and/or capillary lung volume (Vc). TLNO and TLCO were measured in three groups: 22 “normal” subjects (N group), 17 patients receiving MTX, and 12 patients treated with BLM. TLCO, TLNO, Dm, and Vc were much lower in the MTX and BLM groups compared to those of the N one. The ratio TLNO/TLCO was higher in the BLM group compared to that of the N group and compared to that of the MTX group. KCO correlated neither with Dc nor with Vc, whereas TLCO/VI% correlated significantly with both Dm and Vc. Combined measurement of TLCO and TLNO seems to be useful in the followup of patients receiving agents inducing lung toxicity and gives a good idea of the alveolar membrane and the capillary volume.