Table of Contents
Physiology Journal
Volume 2014, Article ID 495926, 5 pages
Research Article

Virgin Coconut Oil: Remedial Effects on Renal Dysfunction in Diabetic Rats

1Department of Human Physiology, Cross River University of Technology, Okuku Campus, Ogoja, Cross River State, Nigeria
2Department of Physiology, Bowen University, Iwo, Osun State, Nigeria

Received 25 May 2014; Accepted 24 June 2014; Published 9 July 2014

Academic Editor: Gary Lopaschuk

Copyright © 2014 A. M. Akinnuga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Renal dysfunction is now a prevalent complication of diabetes mellitus. Therefore, this study was carried out to evaluate the remedial effects of virgin coconut oil (VCO) on renal dysfunction in diabetic rats. Fifteen albino Wistar rats were divided into 3 groups that comprise normal control group (Group I) and diabetic control group (Group II) fed with normal rat chows and a diabetic test group (Group III) fed with 10% VCO diet. Group II and Group III were made diabetic by single intraperitoneal injection of 150 mg/kg of freshly prepared alloxan monohydrate. After 72 hours of alloxan injection, fasting blood glucose was tested to confirm diabetes mellitus. After 3 weeks, the animals were anaesthetized and sacrificed to collect blood samples for renal function analysis. The creatinine, urea, and blood urea nitrogen values of Group II were significantly different from those of Group I and Group III at . Also, there was significant difference () in total protein value between Group II (4.42  ±  0.47 mg/dL) and Group I (5.78  ±  0.12 mg/dL) as well as Group III (5.86  ±  0.19 mg/dL), but there was no significant difference between that of Group I and Group III (5.78  ±  0.12 mg/dL and 5.86  ±  0.19 mg/dL, resp.). Thus, VCO is effective in preventing renal damage in diabetic patients.