Table of Contents
Physiology Journal
Volume 2014, Article ID 920951, 5 pages
Research Article

A Comparative Pathophysiological Study of Normal and Growth Retarded Human Placental Tissue

1Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, PMB 1515, Ilorin 240003, Nigeria
2Department of Physiology, College of Medicine, University of Lagos, PMB 2003, Lagos 220001, Nigeria
3Histopathology Unit, Pathology Department, University of Ilorin Teaching Hospital, PMB 1459, Ilorin 240003, Nigeria
4Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, PMB 2003, Idi-Araba, Lagos 220001, Nigeria
5Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, PMB 5545, Ile-Ife 220005, Nigeria

Received 17 December 2013; Revised 27 March 2014; Accepted 7 April 2014; Published 11 May 2014

Academic Editor: Sharon DeMorrow

Copyright © 2014 Adam Moyosore Afodun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study compares the pathophysiology of normal and growth retarded human placental tissues. Female patients were recruited from the Antenatal Clinic of Dolu Specialist Hospital, Mafoluku, Oshodi, Lagos, between 2008 and 2012. A total of 48 normal term placentas and 15 placentas of known IUGR cases were used for this study. IUGR cases were confirmed on the basis of ultrasound follow-up and diagnosis. Normal term placentas were collected at the point of delivery by a consultant gynaecologist, the cords were clamped, and membranes were then carefully trimmed after which each placenta was weighed. About 1 cm thickness of both normal and growth retarded placenta tissues was cut, processed for hematoxylin and eosin stain, while tissues for enzyme (ALP) assay were homogenized in cold 0.5 M sucrose solution. Comparative analysis of the data was done using ANOVA; was taken as significant. The photomicrographs were observed/studied under light microscope, using the X150 and X600 magnifications. It was revealed therein that placental tissues are homogenous (regionally), compromised of maternal spiral arterioles and deregulated villous vasculogenesis, and that there is a significant difference in the level of alkaline phosphatase enzyme. We therefore concluded that there is a distinct difference between the normal and growth retarded human placenta tissue.