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Pathology Research International
Volume 2010 (2010), Article ID 504584, 5 pages
Case Report

Biliary Adenofibroma of the Liver: Report of a Case and Review of the Literature

1Divisione di Anatomia Patologica, Dipartimento G.F. Ingrassia, Policlinico Universitario-Vittorio Emanuele, Università di Catania, via Santa Sofia 87, 95123 Catania, Italy
2Divisione di Anatomia Patologica, Universita' di Padova, 35122 Padova, Italy
3Dipartimento di Chirurgia, Unità di Gastroenterologia ed Endoscopia, Università di Catania, 95123 Catania, Italy

Received 26 April 2010; Revised 24 July 2010; Accepted 27 July 2010

Academic Editor: Pablo A. Bejarano

Copyright © 2010 Alessandra Gurrera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We herein report the clinicopathologic features of a rare case of biliary adenofibroma (BAF) of the liver in a 79-year-old man. Grossly, tumour presented as a well-circumscribed, 5.5-cm mass with a solid and microcystic appearance. Histological examination was typical of biliary adenofibroma, showing a proliferation of variable-sized tubulocystic structures embedded in a moderately cellular fibrous stroma. Immunohistochemistry, revealing immunoreactivity of the epithelial component to cytokeratins 7 and 19, was consistent with a bile duct origin. Notably, the stromal cells had a myofibroblastic profile, showing a diffuse and strong expression of vimentin and 𝛼 -smooth muscle actin. Differential diagnosis with Von Meyenburg complex, biliary adenoma, biliary cistadenoma, congenital biliary cystsy, and hepatic benign cystic mesothelioma is provided. The occasionally reported expression of p53 in biliary adenofibroma has suggested that this tumour could represent a premalignant lesion. The absence of both cytological atypia and p53 immunoreactivity in our case confirms that BAF is a benign tumour with an indolent clinical behaviour. However, a careful histological examination of BAF is mandatory because malignant transformation of the epithelial component has been documented in two cases.