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Pathology Research International
Volume 2010, Article ID 613824, 4 pages
http://dx.doi.org/10.4061/2010/613824
Case Report

Endobronchial Perineurioma: An Unusual Soft Tissue Lesion in an Unreported Location

1Department of Pathology, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA
2Department of Medicine, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920, USA
3AmeriPath, Indianapolis, IN 46219, USA

Received 5 November 2009; Accepted 15 January 2010

Academic Editor: Paul E. Swanson

Copyright © 2010 Lisa Duncan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report the first case of an endobronchial perineurioma, a rare benign neoplasm typically occurring in soft tissue. A 53-year-old nonsmoking female presented with a three-month history of persistent bronchitis. A CT scan followed by bronchoscopy demonstrated an endobronchial lesion involving the left mainstem bronchus. Removal of the lesion by bronchoscopy was accomplished. The tumor was composed of bland spindle cells in a variably collagenized stroma. These cells had long cytoplasmic processes. No mitotic activity or necrosis was observed. Neoplastic cells were immunoreactive for epithelial membrane antigen (EMA), CD34, and claudin-1. Smooth muscle actin (SMA), desmin, and S-100 immunostains were all negative. Based on the morphologic appearance and immunophenotype, a diagnosis of perineurioma was rendered.