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Pathology Research International
Volume 2010 (2010), Article ID 726829, 4 pages
http://dx.doi.org/10.4061/2010/726829
Case Report

Myofibroblastoma Arising in Mammary Hamartoma: A Case Report

1Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2Departamento de Patologia, Hospital de Clínicas de Porto Alegre, 2350 Porto Alegre, Brazil
3Faculdade de Medicina, Universidade Luterana do Brasil, Canoas, Brazil

Received 23 April 2010; Accepted 5 July 2010

Academic Editor: Gary Tse

Copyright © 2010 Diego M. Uchôa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myofibroblastoma (MFB) is a rare mesenchymal tumor arising in breast's soft tissue with a great variety of microscopic features that can be mistaken with a wide variety of biphasic lesions. The authors report a rare case of myofibroblastoma of the breast arising in a mammary hamartoma (MH), present a review of the clinicopathological features of these lesions, and make some diagnostic considerations. The tumour consisted of a well-circumscribed nodule. MFB component comprised about fifty percent of the lesion and was made up of bipolar spindle cells arranged in fascicular clusters separated by bands of hyalinized collagen. There were fat cells and several residual hamartoma glands intermingled and distorted in MFB area. MFB component was positive for Desmin, CD34, bcl-2, and Calponin. To the best of our knowledge, MFB has not been reported in MH, neither has any of the reports described mammary glands joined within MFB.