Ancillary Studies in Determining Human Papillomavirus Status of Squamous Cell Carcinoma of the Oropharynx: A Review
Figure 1
Poorly-differentiated squamous cell carcinoma lacking clear evidence of squamous differentiation (hematoxylin and eosin) (a). In the oropharynx, these are typically HPV-associated neoplasms. Immunohistochemical stain demonstrates diffuse nuclear and cytoplasmic staining for p16 (b), while in situ hybridization highlights the presence of HPV DNA.
