Ancillary Studies in Determining Human Papillomavirus Status of Squamous Cell Carcinoma of the Oropharynx: A Review
Figure 2
Moderately differentiated squamous cell carcinoma (hematoxylin and eosin) (a) lacking evidence of HPV infection by p16 immunohistochemical stain (b) or in situ hybridization (c). Though well and moderately-differentiated lesions tend to be negative for HPV, and poorly-differentiated lesions are typically HPV positive, there is significant morphologic overlap between HPV positive and negative tumors.
