Effects of the Demethylating Agent, 5-Azacytidine, on Expression of the Kallikrein-Kinin Genes in Carcinoma Cells of the Lung and Pleura
Figure 6
Schematic map showing putative CpG islands in the BDKRB1 and BDKRB2 genes. (a) The BDKRB1 gene on chromosome 14q32.1-32.2 is 8542 bp in length. It has three exons and two introns, with a promoter region extending ~1000 bases upstream of exon 1. Mapping indicated two CpG islands in exon 3. (b) The BDKRB2 gene is also on chromosome 14q32.1-32.2 and is 39,593 bp in length. It has three exons and two introns with a promoter region extending ~1000 bases upstream of exon 1. Mapping indicated five CpG islands in intron 1, exon 3, and the promoter region. The most notable CpG islands were 105 bp and 91 bp in length and were located in the promoter region upstream of exon 1. Two CpG islands were predicted in exon 3.
