PAR Genes: Molecular Probes to Pathological Assessment in Breast Cancer Progression
Figure 2
Activation of PAR1 leads to the association of Etk/Bmx with PAR1 C-tail. This association is mediated through Etk/Bmx PH- domain enabling next the binding of Shc. The site of the “signal binding” domain (e.g., Etk/Bmx, as a prime signaling partner) in PAR1 has been identified. Insertion of successive replacement of A residues forming a PAR1 mutant incapable of binding Etk/Bmx showed impaired capabilities of PAR1 induced invasion and migration. This site provides therefore a platform for the development of future therapeutic medicaments in breast cancer.
