Laminar Distribution of the Pathological Changes in Sporadic and Variant Creutzfeldt-Jakob Disease

Table 2

Frequency of particular types of distribution of the vacuolation, surviving neurons, glial cell nuclei and prion protein (PrP^sc) deposition across the cortical laminae in the cerebral cortex of cases of sporadic Creutzfeldt-Jakob disease (sCJD) and variant CJD (vCJD).

Type of distribution
					Unimodal			Bimodal
Feature	Case	𝑁	NS	RD	𝑈	𝑀	𝐿	𝑈>𝐿	𝑈=𝐿	𝑈<𝐿
Vacuoles	sCJD	43	6	10	3	0	4	7	8	5
	vCJD	58	0	17	9	1	9	7	14	1
Neurons	sCJD	43	4	5	19	0	0	12	3	0
	vCJD	52	12	11	8	0	3	6	10	2
Glia cells	sCJD	42	1	1	0	0	37	0	1	2
	vCJD	57	3	3	2	2	44	0	2	1
PrP^sc	sCJD	31	4	3	2	0	13	4	2	3
Diffuse PrP^sc	vCJD	55	10	3	21	0	7	6	6	1
Florid PrP^sc	vCJD	51	14	1	16	1	6	6	6	1

N: number of neocortical regions studied, NS: no significant difference in density with laminar depth, RD: restrictive distribution, sparing the superficial laminae and the region adjacent to white matter, U: upper cortical laminae, M: middle cortical laminae, L: lower laminae.