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Pathology Research International
Volume 2011 (2011), Article ID 237217, 6 pages
Research Article

Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2/neu, and p53 in Breast Carcinoma

1Department of Pathology, College of Medicine, Hail University, Hail, Saudi Arabia
2Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum 11111, Sudan
3National Oncology Center, Al-Jumhori Teaching Hospital, Sana'a, Yemen
4Faculty of Applied Science, Hail University, Hail, Saudi Arabia

Received 21 June 2011; Accepted 26 August 2011

Academic Editor: Qian Peng

Copyright © 2011 Hussain Gadelkarim Ahmed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Settings. Despite the limited diagnostic utility of AgNORs (argyrophilic nucleolar organiser region-associated proteins) for individual breast lesions, AgNOR analysis bears a significant potential for characterizing cell proliferative activity of breast lesions. Methodology. The present study investigated the relationship between mean AgNORs count and immunohistochemical expression of ER, PR, HER2/neu, and p53 in breast carcinoma in serial paraffin sections from 137 breast carcinomas. Twenty control cases of benign breast lesions were included. Results. Mean AgNOR counts correlated significantly inversely with hormone estrogen receptors (ER), Progesterone receptors (PR), and p53 immunohistochemical expression, denoting 𝑃 values of 0.05, 0.01, and 0.001, respectively. No significant correlation was found between mean AgNOR counts and HER2/neu, 𝑃 = 0 . 9 . Mean AgNOR count was significantly higher in grade II tumor cells. We conclude that mean AgNOR counts correlate with ER, PR, and P53 tumor markers in breast carcinomas. Conclusion. We recommend the use of mean AgNOR count for accurate reporting of breast carcinomas, as well as prediction of ER, PR, and P53 in routine paraffin sections.