From the Bench to Bedside: Biological and Methodology Considerations for the Future of Companion Diagnostics in Nonsmall Cell Lung Cancer

Table 1

Different assays for detection of EGFR mutation that have been used before TKI treatment in phase III trials in the first-line setting.

Study	Assay
Maemondo et al. [15]	Peptide nucleic acid-locked nucleic acid PCR clamp
Mitsudomi et al. [16]	Fragment analysis, Cycleave method, direct sequencing, peptide nucleic acid-locked nucleic acid PCR, PCR invader
Mok et al. [14]	Amplification refractory mutation system (ARMS)