Review Article
From the Bench to Bedside: Biological and Methodology Considerations for the Future of Companion Diagnostics in Nonsmall Cell Lung Cancer
Table 1
Different assays for detection of EGFR mutation that have been used before TKI treatment in phase III trials in the first-line setting.
| Study | Assay |
| Maemondo et al. [15] | Peptide nucleic acid-locked nucleic acid PCR clamp | Mitsudomi et al. [16] | Fragment analysis, Cycleave method, direct sequencing, peptide nucleic acid-locked nucleic acid PCR, PCR invader | Mok et al. [14] | Amplification refractory mutation system (ARMS) |
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