Review Article
Current Concepts on Dedifferentiation/High-Grade Transformation in Salivary Gland Tumors
Table 1
Immunoprofile of dedifferentiated/high-grade transformed areas in salivary gland tumors.
| | Antibodies | Immunoprofile of high-grade transformed areas | | AdCC | AcCC | EMC | PLGA | MEC | MCa |
| | Proliferative antigen | | | | | | | | Ki-67 | HI | HI | HI | HI | HI | HI | | Cytokeratins | | | | | | | | AE1-AE3 |
+
| |
+
|
+
| | | | CAM 5.2 |
+
| NA | |
+
|
−
| NA | | 34bE12 |
+
| NA | | NA | NA | NA | | CK 5/6 | NA |
−
|
+
| NA | NA | NA | | CK 7 | NA |
−
| |
+
| NA | NA | | CK 14 | |
−
| | NA | NA | NA | | CK 20 | NA |
−
| NA |
−
| NA | NA | | Myoepithelial cell | | | | | | | | S-100 | | | | |
−
|
−
| | α-SMA (alfa-smooth muscle actin) | |
−
| |
−
|
−
|
−
| | p63 | | NA | | | NA | NA | | Vimentin | NA |
+
| | | NA |
+
| | Calponin | |
−
|
−
| | NA | NA | | HHF35 (muscle-specific actin) | | NA |
−
| NA | NA | NA | | Desmin | NA | NA |
−
|
−
| NA | NA | | Cell cycle control | | | | | | | | p53 | HI/+ | HI/− | | HI | HI/F |
+
| | Cyclin D1 | | HI |
+
| NA | NA |
+
| | Membrane receptors | | | | | | | | C-kit (CD117) | |
−
| NA | NA |
−
| NA | | HER2/neu (c-erbB2) | |
+
|
−
|
+
|
−
| NA | | EMA (epithelial membrane antigen) |
+
| NA |
+
|
+
|
+
| NA | | Structural proteins | | | | | | | | GFAP (glial fibrillary acidic protein) | | NA |
−
| |
−
| NA | | Cell Adhesion proteins | | | | | | | | CEA (carcinoembryonic antigen) | | NA |
+
| |
−
| NA | | Steroid receptor | | | | | | | | Androgen receptor |
−
|
−
| NA | | NA | NA |
|
|
+: positive expression; −: negative expression; : focal expression; NA: not available; HI: higher index than in conventional area; AdCC: adenoid cystic carcinoma; AcCC: acinic cell carcinoma; EMC: epithelial-myoepithelial carcinoma; PLGA: polymorphous low-grade adenocarcinoma; MEC: mucoepidermoid carcinoma; MCa: myoepithelial carcinoma.
|
