Novel Molecular Markers of Malignancy in Histologically Normal and Benign Breast
Figure 5
Whisker plot showing BUB1B protein expression scores for each individual histologically normal breast tissue with high-grade () and low-grade molecular abnormality () analyzed. The median BUB1B IHC score for each specimen is represented by horizontal lines and symbol +, while mean BUB1B IHC score is represented by Δ. Both mean and median expression scores for the HNB tissues with high-grade molecular abnormality on microarray (cases 1489–1497) are higher than those for the molecularly low-risk HNB tissues with low-grade abnormality on microarray (cases 1480–1488). Overall, there is a greater variation in the expression scores for the HNB tissues with high-grade molecular abnormality as compared to those with low-grade molecular abnormality ( versus 24.8; ). The top row reflects the number of TDLUs that were evaluated for IHC expression of BUB1B protein in the respective stained section, representing each histologically normal breast tissue specimen.
