Novel Molecular Markers of Malignancy in Histologically Normal and Benign Breast
Figure 8
Immunohistochemical expresssion of MCM2 protein in HNB tissues with low-grade and high-grade molecular abnormalities and in IDCs. There is an obvious trend toward increasing expression from HNB tissues with low-grade molecular abnormality (white bars) to those with high-grade molecular abnormality (gray bars), and the IDCs (black bars), thus providing evidence for cross-platform validation of our original expression profiling data for MCM2 at the protein level. (a) Is the specimen-wise distribution of immunohistochemical expression of MCM2 for the HNB tissues with low-grade and high-grade molecular abnormality and IDC groups. (b) Is the pairwise comparison of MCM2 immunostaining among the three groups. The adjusted value for each comparison, based on Tukey method, is shown on (b).
