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Pathology Research International
Volume 2011 (2011), Article ID 605042, 12 pages
Review Article

Tumor Suppressors and Cell-Cycle Proteins in Lung Cancer

1Section of Pathology, Department of Biochemistry, Second University of Naples, 80138 Naples, Italy
2Department of Public Health, Second University of Naples, 80138 Naples, Italy
3Third Division Cotugno Hospital, 80100 Naples, Italy
4SAFU Department, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy

Received 31 December 2010; Accepted 8 August 2011

Academic Editor: Ka F. To

Copyright © 2011 Alfonso Baldi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The cell cycle is the cascade of events that allows a growing cell to duplicate all its components and split into two daughter cells. Cell cycle progression is mediated by the activation of a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors grouped into two families: the INK4 inhibitors (p16, p15, p19, and p18) and the Cip/Kip inhibitors (p21, p27, and p53). Several studies report the importance of cell-cycle proteins in the pathogenesis and the prognosis of lung cancer. This paper will review the most recent data from the literature about the regulation of cell cycle. Finally, based essentially on the data generated in our laboratory, the expression, the diagnostic, and prognostic significance of cell-cycle molecules in lung cancer will be examined.