Nanotherapeutics Using an HIV-1 Poly A and Transactivator of the HIV-1 LTR-(TAR-) Specific siRNA
Figure 6
Confocal images of THP-1 cells treated QR-si510 siRNA nanoplexes: THP-1 cells were treated with QR-si510 siRNA nanoplexes for 12, 48, 96 hr, and up to 1 week and uptake of the nanoplexes was observed using confocal microscopy. (a) Representative local emission spectra confirms that the fluorescence signal in the THP-1 cells is localized to the QR si510 HIV-1siRNA nanoplexes, evident from the sharp emission spectra peak of 625 nm. (b) (A–J): Parallel Fluorescence and transmission images showing fluorescence (red) staining indicating QR-si510 siRNA nanoplex uptake by THP-1 cells.
