Review Article
Penicillium marneffei Infection in AIDS
Table 2
Distinguishing features of microorganisms which may be confused with
Penicillium marneffei in tissue examination [
40,
56,
57].
| | Similarities | Differences |
| Histoplasma capsulatum | Yeast cells with similar staining properties and size Found within histiocytes and similar inflammatory response | Budding instead of septated yeast cells |
| Pneumocystis jiroveci | Cyst form similar size stained positive silver methenamine stain | Round cysts containing single or paired comma shaped argyrophilic foci in walls |
| Leishmania spp. | Amastigotes within histiocytes in H&E section | Presence of bar shaped kinetoplasts within amastigotes seen under oil immersion, PAS stain negative |
| Toxoplasma gondii | May appear as intracellular organisms in H&E section or Giemsa stain | Size smaller, can be found within in other somatic cell types, not stained with silver methenamine |
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H&E: haematoxylin and eosin; PAS: periodic acid-Schiff.
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