Should Histologic Grade Be Incorporated into the TNM Classification System for Small (T1, T2) Node-Negative Breast Adenocarcinomas?

Table 2

Clinical outcome by tumor grade in small (T1, T2) node-negative breast adenocarcinomas.

Tumor Size	T1(𝑁=76)^∗					T2(𝑁=33)
	Clinical Outcome ∗∗					Clinical Outcome ∗∗
	Without Disease		With Disease			Without Disease		With Disease
Tumor Grade	𝑁	%	𝑁	%	𝑃^∗∗∗	𝑁	%	𝑁	%	𝑃^∗∗∗
G1-G2	50	66	2	3		17	52	0	0
G3	24	31	0	0	.46	12	36	4	12	.04

∗Excludes 2 alive, status unknown.
∗∗Clinical outcome includes patients living and deceased.
∗∗∗The 𝑝-value is for a one-tailed Fisher exact test.