Hereditary Diffuse Gastric Cancer: Multidisciplinary Case Report with Review of the Literature
Figure 2
(a) Focal intramucosal signet-ring cell adenocarcinoma in case study patient with known CDH1 mutation. Insert highlights area of pagetoid spread. (b) Focal absence of E-Cadherin staining highlights the tumor cluster in case study patient. In those HDGC cases in which tumor cells show decreased E-cadherin expression, the normal background epithelium serves as an excellent internal control.
