Histopathological and Genomic Grading Provide Complementary Prognostic Information in Breast Cancer: A Study on Publicly Available Datasets

Table 2

Showing the hazard ratios for recurrence-free survival for each combination of histopathological and genomic grade. (HG = histopathological grade, GG1 = low genomic grade, and GG3 = high genomic grade). Values marked with an asterisk (*) are unstable due to scanty number of cases.

	All tumors		ER+ve tumors		ER+ve Node −ve tumors		ER+ve Stage I tumors		ER+ve Node +ve tumors
	HR	95%CI; 𝑃	HR	95%CI; 𝑃	HR	95%CI; 𝑃	HR	95%CI; 𝑃	HR	95%CI; 𝑃
HG1-GG3 versus HG1-GG1	5.1	2.6–10.0; (<0.001)	5.5	2.4–12.8; (<0.001)	3.4	1.5–8.0; (0.004)	3.7	1.1–12.4; (0.04)	19.6*	3.5–110*; (<0.001)
HG2-GG1 versus HG1-GG1	2.8	1.7–4.7; (<0.001)	2.6	1.5–4.4; (<0.001)	1.9	1.3–2.7; (0.001)	1.7	1.1–2.7; (0.02)	6.8	1.4–33.2; (0.02)
HG2-GG3 versus HG1-GG1	5.8	3.9-8.5; (<0.001)	5.6	3.8-8.2; (<0.001)	4.5	3.4-6.0; (<0.001)	6.0	3.5-10.3; (<0.001)	11.4	2.8–46.9; (0.001)
HG3-GG1 versus HG1-GG1	3.6	1.9–6.6; (<0.001)	3.4	1.7–6.7; (<0.001)	2.8	1.3–6.4; (0.01)	4.5	1.9–10.4; (<0.001)	8.9*	2.0–39*; (0.004)
HG3-GG3 versus HG1-GG1	4.9	3.2–7.6; (<0.001)	5.2	3.7–7.4; (<0.001)	4.8	3.2–7.4; (<0.001)	6.1	2.9–12.8; (<0.001)	7.9	2.3–27.7; (0.001)