Histopathological and Genomic Grading Provide Complementary Prognostic Information in Breast Cancer: A Study on Publicly Available Datasets

Table 3

Showing the hazard ratios for distant metastasis-free survival for each combination of histopathological and genomic grade (HG = histopathological grade, GG1 = low genomic grade, and GG3 = high genomic grade). Values marked with an asterisk (*) are unstable due to scanty number of cases.

	All tumors		ER+ve tumors		ER+ve Node −ve tumors		ER+ve Stage I tumors		ER+ve Node +ve tumors
	HR	95%CI; 𝑃	HR	95%CI; 𝑃	HR	95%CI; 𝑃	HR	95%CI; 𝑃	HR	95%CI; 𝑃
HG1-GG3 versus HG1-GG1	4.8	2.1–10.8; (<0.001)	4.7	1.8–12.5; (0.002)	2.5	0.8–7.6; (0.1)	2.1	0.4–10.6; (0.4)	22.3*	3.1–162*; (0.002)
HG2-GG1 versus HG1-GG1	2.2	1.2–4.2; (0.01)	2.0	1.04–3.8; (0.04)	1.3	0.8–2.3; (0.3)	0.9	0.4–2.2; (0.8)	7.5	0.8–73.1; (0.08)
HG2-GG3 versus HG1-GG1	5.6	3.7–8.7; (<0.001)	5.3	3.2–8.6; (<0.001)	3.9	2.3–6.8; (<0.001)	4.7	2.2–10.3; (<0.001)	14.1	1.8–110; (0.01)
HG3-GG1 versus HG1-GG1	3.8	1.9–7.5; (<0.001)	3.7	1.7–7.9; (<0.001)	2.8	1.2–6.4; (0.02)	3.9	1.5–10.0; (0.005)	22.6*	2.8–183*; (0.003)
HG3-GG3 versus HG1-GG1	5.0	2.7–9.2; (<0.001)	5.1	3.1–8.5; (<0.001)	4.2	2.3–7.8; (<0.001)	6.0	2.3–15.4; (<0.001)	8.7	1.7–43.5; (0.008)