Histopathological and Genomic Grading Provide Complementary Prognostic Information in Breast Cancer: A Study on Publicly Available Datasets

Table 4

Showing the correlation of scaled Schoenfeld residuals for each combination of histopathological and genomic grade with time for histopathological and genomic grade (rho = correlation coefficient, HG = histopathological grade, GG1 = low genomic grade, and GG3 = high genomic grade). A significant correlation shows time-dependent covariate effects. Negative correlation means that the prognostic effects get attenuated over time, and a positive correlation means that the prognostic effects get strengthened over time.

	Alldata		ER+ve		ER+ve Node −ve		ER+ve Stage I
	rho	𝑃	rho	𝑃	rho	𝑃	rho	𝑃
RFS
HG1-GG3	0.04	0.5	−0.07	0.3	−0.09	0.2	−0.09	0.4
HG2-GG1	0.11	0.6	−0.01	0.9	0.08	0.4	0.04	0.8
HG2-GG3	0.12	0.02	0.01	0.9	0.11	0.1	−0.21	0.2
HG3-GG1	− 0.18	<0.001	−0.08	0.2	− 0.14	0.007	−0.12	0.2
HG3-GG3	− 0.30	<0.001	− 0.16	0.05	− 0.22	<0.001	− 0.23	0.01
DMFS
HG1-GG3	0.08	0.3	0.00	1	0.12	0.2	−0.08	0.6
HG2-GG1	−0.01	0.9	0.02	0.8	-0.05	0.7	−0.02	0.9
HG2-GG3	−0.03	0.7	−0.04	0.7	− 0.28	0.02	− 0.38	0.03
HG3-GG1	− 0.21	<0.001	−0.09	0.3	− 0.17	0.07	− 0.30	0.09
HG3-GG3	−𝟎 .29	<0.001	− 0.17	0.06	− 0.29	0.003	− 0.39	0.01