Histopathological and Genomic Grading Provide Complementary Prognostic Information in Breast Cancer: A Study on Publicly Available Datasets

Table 5

Illustrating the time changing prognostic effects of histopathological grading. The table compares the hazard ratios of histopathological and genomic grading for the first seven years to the hazard ratios of the same from seven years onwards. This analysis was performed on the entire dataset.(HR = hazard ratio, HG = histopathological grade, GG1 = low genomic grade, and GG3 = high genomic grade).

	Recurrence-free survival		Distant metastasis-free survival
	HR(0–7 yrs) (95% CI)	HR(7 yrs-EOS) (95% CI)	HR(0–7 yrs) (95% CI)	HR(7 yrs-EOS) (95% CI)
HG1-GG3 versus HG1-GG1	10.0 (4.0–24.9)	1.4 (0.2–9.0)	26.5 (4.7–149)	1.1 (0.2–5.6)
HG2-GG1 versus HG1-GG1	4.6 (1.9–11.4)	1.5 (0.8–2.6)	9.6 (1.4–66.2)	0.9 (0.4–2.1)
HG2-GG3 versus HG1-GG1	11.0 (5.3–22.7)	1.8 (0.9–3.8)	32.1 (5.1–202)	1.2 (0.3–4.3)
HG3-GG1 versus HG1-GG1	7.4 (3.6–14.8)	0.5 (0.1–3.9)	22.7 (3.6–144)	0.4 (0.05–3.7)
HG3-GG3 versus HG1-GG1	10.3 (5.3–20.1)	0.7 (0.3–1.9)	31.6 (5.6–179)	0.5 (0.2–1.3)