Chronic Proliferative Dermatitis in Mice: NFκB Activation Autoinflammatory Disease

Figure 1

Chronic hyperproliferative dermatitis with loss of body weight. Longitudinal macroscopic observations at 5 time points (2-, 4-, 6-, 8-, and 10-week) found progressive development of dermatitis in Sharpin^cpdm mutant mice (a)–(e), compared to the representative of wildtype mice at the age of 10 weeks (f). Hair loss and skin redness can be carefully found at forehead in 2-week-old mutant and gradually develop toward the posterior end of body. After the age of 6 weeks, pigmented skin islands formed containing broken hair shafts in skin and inflammatory pigmentation, covered with small, scurfy scales. Skin openings occur at the hairless areas after 6 weeks of age and gradually became deeper and wider until 10-week old. Histologically, increasing of epidermal thickness is consistent with the severity of epidermal hyperproliferation (g)–(m). Keratinocyte mitosis and apoptosis were quantitatively analyzed at each time point (m, n). Compared to wildtypes, the mutant mice present slower growth of body weight at the beginning of 4 weeks of age and lose body weight after 8 weeks of age (p).

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