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Figure 4: Expression changes of keratin and filaggrin in skin. (a, b): K5 expression in the basal layer of the epidermis of 10-week-old wild-type mice (a) but in the whole epidermis, preferentially in the basal layer, of 10-week-old Sharpincpdm mice (b). (c, d): K14 expression in the basal layer of the epidermis of 10-week-old wild-type mice (c). K14 was uniformly expressed in the whole epidermis of 10-week-old Sharpincpdm mice (d). (e, f): K1 expression locates in suprabasal layer of the epidermis of 10-week-old wild-type mice (e) but limited to the outer layers of the stratum spinosum of 10-week-old Sharpincpdm mice (f). (g, h): K10 expression is located at the suprabasal layers of the epidermis and hair follicle of 10-week-old wild-type mice (g) but limited to the outer layers of the stratum spinosum of the epidermis and hair follicle of 10-week-old Sharpincpdm mice (h). (i, j): K6 is only expressed in the hair follicle of 10-week-old wild-type mice (i) but widely expressed in both hair follicle and interfollicle epidermis of 10-week-old Sharpincpdm mice (j). (k, l): Filaggin expression in the granular layers of the epidermis of 10-week-old normal and mutant mice.