Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their Molecular Aspects

Figure 2

Schematic of Wnt signaling pathway. In demoid tumors, mutations are usually found in the APC gene or CTNNB1 gene, which encodes β-catenin. Regardless of the primary defect, the end result is nuclear accumulation of β-catenin, which fails to undergo cytoplasmic degradation.