Table of Contents Author Guidelines Submit a Manuscript
Pathology Research International
Volume 2012, Article ID 201375, 8 pages
http://dx.doi.org/10.1155/2012/201375
Clinical Study

Gastric Composite Tumor of Alpha Fetoprotein-Producing Carcinoma/Hepatoid Adenocarcinoma and Endocrine Carcinoma with Reference to Cellular Phenotypes

1Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
2Department of Clinical Laboratory Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
3Biomedical Laboratory Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-0802, Japan

Received 15 September 2011; Revised 14 November 2011; Accepted 12 December 2011

Academic Editor: Marco Volante

Copyright © 2012 Akira Suzuki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Gitlin, A. Perricelli, and G. M. Gitlin, “Synthesis of -fetoprotein by liver, yolk sac, and gastrointestinal tract of the human conceptus,” Cancer Research, vol. 32, no. 5, pp. 979–982, 1972. View at Google Scholar · View at Scopus
  2. Y. C. Chang, N. Nagasue, S. Abe, H. Taniura, D. D. Kumar, and T. Nakamura, “Comparison between the clinicopathologic features of AFP-positive and AFP- negative gastric cancers,” American Journal of Gastroenterology, vol. 87, no. 3, pp. 321–325, 1992. View at Google Scholar · View at Scopus
  3. K. R. McIntire, T. A. Waldmann, C. G. Moertel, and V. L. Go, “Serum α-fetoprotein in patients with neoplasms of the gastrointestinal tract,” Cancer Research, vol. 35, no. 4, pp. 991–996, 1975. View at Google Scholar · View at Scopus
  4. H. Ishikura, K. Kirimoto, M. Shamoto et al., “Hepatoid adenocarcinomas of the stomach: an analysis of seven cases,” Cancer, vol. 58, no. 1, pp. 119–126, 1986. View at Google Scholar · View at Scopus
  5. N. Koide, A. Nishio, J. Igarashi, S. Kajikawa, W. Adachi, and J. Amano, “α-Fetoprotein-producing gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis,” American Journal of Gastroenterology, vol. 94, no. 6, pp. 1658–1663, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Matsui, M. Kitagawa, A. Miwa, Y. Kuroda, and M. Tsuji, “Small cell carcinoma of the stomach: a clinicopathologic study of 17 cases,” American Journal of Gastroenterology, vol. 86, no. 9, pp. 1167–1174, 1991. View at Google Scholar · View at Scopus
  7. K. Matsui, X. M. Jin, M. Kitagawa, and A. Miwa, “Clinicopathologic features of neuroendocrine carcinomas of the stomach: appraisal of small cell and large cell variants,” Archives of Pathology and Laboratory Medicine, vol. 122, no. 11, pp. 1010–1017, 1998. View at Google Scholar · View at Scopus
  8. N. Koide, A. Suzuki, H. Saito et al., “Gastric small cell carcinoma successfully treated by surgery and postoperative chemotherapy consisting of cisplatin and S-1: report of a case,” Surgery Today, vol. 37, no. 11, pp. 989–994, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. A. Japanese Gastric Cancer, “Japanese classification of gastric carcinoma—2nd english edition,” Gastric Cancer, vol. 1, no. 1, pp. 10–24, 1998. View at Google Scholar
  10. M. Tatematsu, T. Tsukamoto, and K. Inada, “Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia,” Cancer Science, vol. 94, no. 2, pp. 135–141, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. S. K. Chang, A. F. Dohrman, C. B. Basbaum et al., “Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer,” Gastroenterology, vol. 107, no. 1, pp. 28–36, 1994. View at Google Scholar · View at Scopus
  12. C. de Bolos, M. Garrido, and F. X. Real, “MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach,” Gastroenterology, vol. 109, no. 3, pp. 723–734, 1995. View at Publisher · View at Google Scholar · View at Scopus
  13. S. B. Ho, A. M. Roberton, L. L. Shekels, C. T. Lyftogt, G. A. Niehans, and N. W. Toribara, “Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression,” Gastroenterology, vol. 109, no. 3, pp. 735–747, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. D. G. Silberg, G. P. Swain, E. Ran. Suh, and P. G. Traber, “Cdx1 and Cdx2 expression during intestinal development,” Gastroenterology, vol. 119, no. 4, pp. 961–971, 2000. View at Google Scholar · View at Scopus
  15. X. L. Li, Y. Eishi, Y. Q. Bai et al., “Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma,” International Journal of Oncology, vol. 24, no. 2, pp. 257–263, 2004. View at Google Scholar · View at Scopus
  16. F. T. Bosman, F. Carneiro, R. H. Hruban, and N. D. Theise, WHO Classification of Tumours of the Digestive System, 4th edition, 2010.
  17. Y. Kumashiro, T. Yao, S. Aishima et al., “Hepatoid adenocarcinoma of the stomach: histogenesis and progression in association with intestinal phenotype,” Human Pathology, vol. 38, no. 6, pp. 857–863, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. T. Okamoto, K. Ogasahara, M. Fujiki et al., “Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes,” Journal of Gastroenterology, vol. 38, no. 6, pp. 608–610, 2003. View at Google Scholar · View at Scopus
  19. G. Z. Rassidakis, J. K. Delladetsima, S. P. Letsos, A. Polyzos, and A. Yannopoulos, “Hepatoid adenocarcinoma of the stomach with extensive neuroendocrine differentiation and a coexisting carcinoid tumour,” Histopathology, vol. 33, no. 2, pp. 186–188, 1998. View at Google Scholar · View at Scopus
  20. T. Ueda, H. Neduka, S. Yamamoto et al., “A case of advanced gastric cancer of poorly differentiated adenocarcinoma associated with endocrine cell carcinoma element (in Japanese),” Rinsho Geka / Journal of Clinical Surgery, vol. 58, no. 7, pp. 1009–1012, 2003. View at Google Scholar
  21. S. Akiyama, G. Tamura, Y. Endoh et al., “Histogenesis of hepatoid adenocarcinoma of the stomach: molecular evidence of identical origin with coexistent tubular adenocarcinoma,” International Journal of Cancer, vol. 106, no. 4, pp. 510–515, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. T. Motoyama, K. Aizawa, T. Fujiwara, Y. Endoh, and H. Watanabe, “Coexistence of choriocarcinoma and hepatoid adenocarcinoma in the stomach,” Pathology International, vol. 44, no. 9, pp. 716–721, 1994. View at Google Scholar · View at Scopus
  23. T. Kishimoto, Y. Nagai, K. Kato, D. Ozaki, and H. Ishikura, “Hepatoid adenocarcinoma: a new clinicopathological entity and the hypotheses on carcinogenesis,” Medical Electron Microscopy, vol. 33, no. 2, pp. 57–63, 2000. View at Publisher · View at Google Scholar · View at Scopus
  24. G. C. Yang and H. Rotterdam, “Mixed (composite) glandular-endocrine cell carcinoma of the stomach. A report of a case and review of literature,” American Journal of Surgical Pathology, vol. 15, no. 6, pp. 592–598, 1991. View at Google Scholar · View at Scopus
  25. N. Rayhan, T. Sano, Z. R. Qian, A. K. Obari, and M. Hirokawa, “Histological and immunohistochemical study of composite neuroendocrine-exocrine carcinomas of the stomach,” Journal of Medical Investigation, vol. 52, no. 3-4, pp. 191–202, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Nishikura, H. Watanabe, M. Iwafuchi, T. Fujiwara, K. Kojima, and Y. Ajioka, “Carcinogenesis of gastric endocrine cell carcinoma: analysis of histopathology and p53 gene alteration,” Gastric Cancer, vol. 6, no. 4, pp. 203–209, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. O. Hameed, H. Xu, S. Saddeghi, and H. Maluf, “Hepatoid carcinoma of the pancreas: a case report and literature review of a heterogeneous group of tumors,” American Journal of Surgical Pathology, vol. 31, no. 1, pp. 146–152, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. R. Yamaguchi, O. Nakashima, T. Ogata, K. Hanada, T. Kumabe, and M. Kojiro, “Hepatocellular carcinoma with an unusual neuroendocrine component,” Pathology International, vol. 54, no. 11, pp. 861–865, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. M. Iwafuchi, F. Kusama, T. Watanabe et al., “Endocrine cell carcinoma of the stomach (in Japanese),” Byori to Rinsho (Pathology and Clinical Medicine), vol. 23, no. 9, pp. 966–973, 2005. View at Google Scholar
  30. T. Tsukamoto, K. Inada, H. Tanaka et al., “Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia,” Journal of Cancer Research and Clinical Oncology, vol. 130, no. 3, pp. 135–145, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. T. Tsukamoto, T. Mizoshita, M. Mihara et al., “Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes,” Histopathology, vol. 46, no. 6, pp. 649–658, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. H. Seno, M. Oshima, M. A. Taniguchi et al., “CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: prognostic implications,” International Journal of Oncology, vol. 21, no. 4, pp. 769–774, 2002. View at Google Scholar · View at Scopus
  33. R. Almeida, E. Silva, F. Santos-Silva et al., “Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas,” Journal of Pathology, vol. 199, no. 1, pp. 36–40, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus