Table of Contents
Pathology Research International
Volume 2012, Article ID 350309, 6 pages
Review Article

Clinicopathological Features and Management of Cancers in Lynch Syndrome

Department of Gastroenterological Surgery, Jyväskylä Central Hospital, 40620 Jyväskylä, Finland

Received 2 December 2011; Accepted 28 February 2012

Academic Editor: George L. Mutter

Copyright © 2012 Markku Aarnio. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Lynch syndrome (LS) is characterized by an autosomal dominant inheritance of the early onset of colorectal cancer (CRC) and endometrial cancer, as well as increased risk for several other cancers including gastric, urinary tract, ovarian, small bowel, biliary tract, and brain tumors. The syndrome is due to a mutation in one of the four DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2. The majority of LS patients and families can now be identified, and the underlying mutation detected using genetic diagnostics. Regular surveillance for CRC and endometrial cancer has proved beneficial for mutation carriers. However, screening for other tumors is also recommended even though experiences in the screening of these tumors is limited. Prophylactic colectomy, prophylactic hysterectomy, and bilateral salpingo-oophorectomy may be reasonable options for selected patients with LS. This paper describes the features and management of LS.