Genetic and Epigenetic Events Generate Multiple Pathways in Colorectal Cancer Progression

Table 1

Components of the SWI/SNF complex and their biological roles in colorectal cancer.

SWI/SNF components in mammals
Members	Gene	Biological relevance	References
BRM	SMARCA2	(i) Mutated or lost in CRC cell lines	[45, 46, 49, 54]
		(ii) TSG
BRG1	SMARCA4	(i) Mutated or lost in CRC cell lines	[48–50, 52, 53]
		(ii) EMT in CRC
		(iii) TSG
BAF170	SMARCC2	(i) CRC?	[46, 47]
		(ii) ESC self-renewal pluripotency
BAF155	SMARCC1	(i) CRC?	[46, 47]
		(ii) ESC self-renewal pluripotency
HLTF	SMARCA3	(i) TSG in CRC	[61]
BAF47	SMARCB1	(i) CRC?	[46, 55–58]
		(ii) TSG

SWI: mating-type switching; SNF: sucrose nonfermenting; BRM: brahma; BRG1: brahma-related gene-1; BAFs: BRG- and BRM- associated factors; TSG: tumor suppressor gene; CRC: colorectal cancer; HLTF: helicase-like transcription factor; EMT: epithelial mesenchymal transition; ESC: embryonic stem cells. CRC? indicates a yet unknown role in colorectal cancer.
Note: representative SWI/SNF components are shown; at least 15 subunits have been described in mammals so far.