Fibroblast Growth Factor Receptor 2: Expression, Roles, and Potential As a Novel Molecular Target for Colorectal Cancer

Figure 1

Alternative splicing of FGFR2 and specific ligands of each variant. The two FGFR2 isoforms are generated by alternative splicing of exons 8 and 9. This alternative splicing determines the specific ligands for each FGFR2 isoform [19]. FOX-2 or ESRP1 and 2 bind to the ISE/ISS-3 element to enhance splicing of exon 8 and silencing of exon 9.