Evidences Suggesting Involvement of Viruses in Oral Squamous Cell Carcinoma

Table 2

Studies on HPV in oral squamous cell carcinoma.

Study/year	Geographic location	Tumour site(s)	No. of cases	HPV +ve; 𝑁 (%)	Genotype(s)	DNA; method
Loning et al., 1985 [48]	Germany	Oscc	6	50%	16, 11	SB
Maitland et al., 1987 [49]	United Kingdom	Oscc	15	46.7%	16	SB
Gassenmaier and Hornstein, 1988 [50]	Germany	Oscc	68	23.5%	16	ISH
Syrjänen et al., 1988 [51]	Finland	Oscc	51	11.8%	16, 18	ISH
Chang et al., 1990 [52]	Finland	Oscc	40	2.5; 27.5%	16	ISH; PCR
Greer et al., 1990 [53]	USA	Oscc	100	6%	n.d	ISH
Kashima et al., 1990 [54]	USA	Oscc	26	19.2%		SB
Young and Min et al., 1991 [55]	USA	Oscc	27	0%	6, 11, 16, 18, 31, 33, 35	PCR
Zeuss et al., 1991 [56]	Spain	Oscc	15	0%	6, 11	ISH
Holladay and Gerald, 1993 [57]	USA	Oscc	39	17.9%	16	PCR
Cox et al., 1993 [58]	UK	Oscc	8	50%	16	SB
Brandwein et al., 1994 [59]	USA	Oscc	64	25%	16	PCR
González-Moles et al., 1994 [60]	Spain	Oscc	27	37%	6, 11	ISH
Ostwald et al., 1994 [61]	Germany	Oscc	26	61.5%	16, 18	PCR
Balaram et al., 1995 [62]	India	Oscc	91	73.6%	6, 11, 16, 18	PCR
Shindoh et al., 1995 [63]	Japan	Oscc	77	31.2%	16	PCR
Van Rensburg et al., 1995 [64]	South Africa	Oscc	66	1.5%	18	ISH
Cruz et al., 1996 [65]	The Netherlands	Oscc	35	54.3%	16	PCR
Mao et al., 1996 [66]	USA	Oscc	64	31%	n.d.	PCR
Van Rensburg et al., 1996 [67]	South Africa	Oscc	146	1.4%	11, 16	PCR
Chiba et al., 1996 [68]	Japan	Oscc	38	21%	16, 18, 33	PCR
Wen et al., 1997 [69]	Japan	Oscc	45	31.1%	16, 18	PCR
Gopalakrishnan et al., 1997 [70]	USA	Oscc	10	30%	16	PCR
Ibrahim et al., 1998 [71]	Sudan	Oscc	88	0; 0%	n.d.	ISH; PCR
Koh et al., 1998 [72]	Korea	Oscc	42	52%	n.d.	PCR
Premoli-De-Percoco et al., 1998 [73]	Venezuela	Oscc	50	70%	16, 18	ISH
D’Costa et al., 1998 [74]	India	Oscc	100	15%	16, 18	PCR
Schwartz et al., 1998 [33]	USA	Oscc	193	21.2%	16	PCR
Elamin et al., 1998 [75]	UK	Oscc	28	50%	6, 16	PCR
Aggelopoulou et al., 1999 [76]	Greece	Oscc	81	49%	n.d	PCR
Pillai et al., 1999 [77]	India	Oscc	61	16.8%	16	PCR
Pintos et al., 1999 [78]	Canada	Oral cavity	29	10%	n/s	PCR
Badaracco et al., 2000 [79]	Italy	Oscc	66	36.4%	16, 6	PCR
Bouda et al., 2000 [80]	Greece	Oscc	19	94.7%	16, 18, 33	PCR
Cao et al., 2000 [81]	China	Oscc	40	72.5%	16, 18	PCR
Patima Cao et al., 2000 [82]	China	Oscc	73	74%	16, 18	PCR
Sand et al., 2000 [83]	Sweden	Oscc	24	12.5%	16, 18, 6, 11	PCR
Tsuhako et al., 2000 [84]	Japan	Oscc	83	56.9%	n.d.	PCR
Gillison et al., 2000 [30]	USA	Oscc	84	11.9%	16	PCR & ISH & SB
Bouda et al., 2000 [80]	Greece	Oscc	19	89.5%	16, 18	PCR
Premoli-De-Percoco and Ramirez 2001 [85]	Venezuela	Oscc	50	60%	16, 18	PCR
Schwartz et al., 2001 [86]	USA	Oscc	254	24.4%	16	PCR
Chen et al., 2002 [87]	Taiwan	Oscc	29	82.7%	16, 18, 6	PCR
Kojima et al., 2002 [88]	Japan	Oscc	53	66%	38	PCR
Nagpal et al., 2002 [89]	India	Oscc	110	33.6%	16, 18	PCR
Chang et al., 2003 [90]	Japan	Oscc	103	49.5%	HR	PCR
Fregonesi et al., 2003 [91]	Brazil	Oscc	46	39%	16, 18, 6, 11	ISH
Kansky et al., 2003 [92]	Slovenia	Oscc	62	95%	16, 33, 58, 11, 31, 68	PCR
Ritchie et al., 2003 [93]	USA	Oscc	141	15%	16, 33	PCR
Sugiyama et al., 2003 [94]	Japan	Oscc	86	34.8%	16	PCR
Herrero et al., 2003 [95]	France	Oscc	58	5.17%	16	PCR
Ostwald et al., 2003 [96]	Germany	Oscc	118	43.2%	6, 11, 16, 18	PCR/SB
Correnti et al., 2004 [97]	Venezuela	Oscc	16	50%	HR	PCR
Dahlgren et al., 2004 [98]	Sweden	Oscc	110	10.9%	16	PCR
Smith et al., 2004 [99]	USA	Oscc	106	9.4%	16, 33	PCR
Zhang et al., 2004 [100]	Japan	Oscc	73	34%	16, 18	PCR
Yang et al., 2004 [101]	Taiwan	Oscc	37	10.8%	16, 18	PCR
Koppikar et al., 2005 [102]	India	Oscc	101	31.7%	16, 18	PCR
Lo Muzio et al., 2005 [103]	Italy	Oscc	18	50%	n.d.	PCR
Boy et al., 2006 [104]	South Africa	Oscc	59	11%	18	PCR; ISH
El-Mofty and Patil 2006 [105]	USA	Oscc	94	30%	16, 31, 33	PCR
Nemes et al., 2006 [106]	Hungary	Oscc	79	41.7%	16	PCR
Rivero and Nunes 2006 [107]	Brazil	Oscc	23	0%	n.d.	PCR
Campisi et al., 2006 [108]	Italy	Oscc	63	38.1%	n.d	PCR
Furrer et al., 2006 [109]	Argentina	Oscc	14	42.8%	16, 18	PCR/SB
Koyama et al., 2007 [110]	Japan	Oscc	20	100%	18, 22, 16, 70	PCR
Sugiyama et al., 2007 [111]	Japan	Oscc	66	100%	16	PCR
Luo et al., 2007 [112]	Taiwan	Oscc	51	73%	—	PCR
Khovidhunkit et al., 2008 [113]	Thailand	Oscc	65	1.54%	16, 18	PCR
Szarka et al., 2009 [114]	Hungary	Oscc	65	47.7%	16, 18	PCR
Zhao et al., 2009 [115]	China	Oscc	52	40.4%	16, 18, 11, 6	PCR
Attner et al., 2010 [116]	Sweden	Oscc	87	68 (78)%	16, 33	PCR
Elango et al., 2011 [117]	India	Oscc	60	48%	16	PCR/IHC
Kristoffersen et al., 2012 [118]	Norway	Oscc	50	30%	6, 11, 16	PCR
Chen et al., 2012 [119]	Taiwan	Oscc	64	39%	16	ISH/IHC
Lee et al., 2012 [120]	Taiwan	Oscc	173	22%	16, 18	PCR

PCR: polymerase chain reaction; SB: southern blotting; ISH: in situ hybridization; IHC: immunohistochemistry.