Table of Contents
Pathology Research International
Volume 2014, Article ID 104962, 7 pages
Research Article

Bone Marrow Mesenchymal Stem Cells Ameliorates Seawater-Exposure-Induced Acute Lung Injury by Inhibiting Autophagy in Lung Tissue

1Third Ward of VIP, 323 Hospital of PLA, Xi’an 710054, China
2Pathology Department, Medical School, Xi’an Jiaotong University, Xi’an 710061, China
3Ward of VIP, Shaanxi People’s Hospital, Xi’an 710068, China
4Department of Endocrinology, The First Hospital of PLA, Lanzhou 730000, China
5Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an 710038, China
6Electric Power Science Research Institute of Shaanxi Province, Xi’an 710054, China

Received 12 March 2014; Revised 25 July 2014; Accepted 25 July 2014; Published 19 August 2014

Academic Editor: Piero Tosi

Copyright © 2014 Qiu-ping Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Seawater drowning can lead to acute lung injury (ALI). Several studies have shown that bone marrow mesenchymal stem cells (BMSC) treatment could attenuate ALI. However, the mechanisms underlying this phenomenon still remain elusive. Therefore, this study aimed to investigate whether BMSC treatment can ameliorate seawater-induced ALI and its underlying mechanisms in a rat model. In this study, arterial blood gas, lung weight coefficient, and TNF-α, and IL-8 in bronchoalveolar lavage fluid (BALF), as well as histopathology examination, were used to detect the lung injury of seawater exposure. Moreover, western blot and RT-PCR were used to explore autophagy in lung tissues. The results demonstrated that seawater exposure induced ALI including impaired arterial blood gas, pulmonary edema, histopathologic changes, and inflammatory response in lung tissues. What is more, these changes were partly ameliorated by BMSC treatment through inhibition of autophagy in lung tissues. The application of BMSC may be a potential effective treatment for seawater-induced ALI.