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Pathology Research International
Volume 2014, Article ID 141864, 6 pages
http://dx.doi.org/10.1155/2014/141864
Research Article

Correlation of CK5 and EGFR with Clinicopathological Profile of Triple-Negative Breast Cancer

1Department of Pathology, Deen Dayal Upadhyay Hospital, Hari Nagar, New Delhi 110066, India
2Department of Pathology, Saraswathi Institute of Medical Sciences, Anwarpur, Hapur, Uttar Pradesh 245304, India

Received 12 May 2014; Revised 30 September 2014; Accepted 12 October 2014; Published 23 October 2014

Academic Editor: Luigi M. Terracciano

Copyright © 2014 Neelam Sood and Jitendra Singh Nigam. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and Her2neu expressions. The aim of this study was to examine the expression of the EGFR, CK5, and Ki-67 among triple-negative breast cancer cases and to correlate the expression of the basal markers with the clinicopathological prognostic parameters. Materials and Methods. Thirty-six female patients with TNBC based on ER, PR, and the HER2neu negativities were studied by immunohistochemistry for EGFR, CK5, and Ki-67 expression. Statistical analysis was done using the SPSS software version 20. Results. The mean and median ages were 45.18 years and 46.70 years, respectively. Infiltrating ductal carcinoma NOS was the predominant histopathological type (29/36 [80.6%]). The commonest histological grade was grade 2 (17/36 [47.2%]). Tumour necrosis was seen in 16/36 (44.4%) patients. Infiltrative margins were shown in 69.44% (25/36) cases. Ki-67 was positive in 80.56% (29/36) cases, 61.11% (22/36) were CK5-positive, and 86.11% (31/36) were EGFR-positive. The only significant positive association observed was between the CK5 and histological grade (). Conclusion. CK5 shows a statistically significantly correlation with TNBC histological grade. The majority of the specimens show EGFR expression. Therefore TNBCs could potentially benefit from EGFR-targeted therapeutic strategies.