Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens

Table 5

MMP-2 and MMP-9 expression and recurrence regarding cut-off values determined by the Youden index.

		Youden index	95% CI	Associated criterion	Sensitivity	95% CI	Specificity	95% CI
MMP-2	all margins	0.2609	0.1405 to 0.3344	>52.5	100.00	75.3 to 100.0	26.09	10.2 to 48.4
MMP-2 TM	all	0.1679	0.1203 to 0.1839	>158.33	23.81	8.2 to 47.2	92.98	83.0 to 98.1
	neg.; margin	0.2475	0.1605 to 0.2910	≤90	76.92	46.2 to 95.0	47.83	26.8 to 69.4
	pos.; margin	0.3456	0.1471 to 0.4632	>90	87.50	47.3 to 99.7	47.06	29.8 to 64.9
MMP-9	all margins	0.1827	0.1314 to 0.189	≤115	30.77	9.1 to 61.4	87.50	67.6 to 97.3
MMP-9 TM	all	0.2553	0.1242 to 0.3941	>141.67	65.22	42.7 to 83.6	60.32	47.2 to 72.4
	neg.; margin	0.1731	0.1314 to 0.1795	>195	7.69	0.2 to 36.0	75.00	53.3 to 90.2
	pos.; margin	0.3974	0.1729 to 0.5718	>175	50.00	18.7 to 81.3	89.74	75.8 to 97.1

CI: confidence interval; TM: tumor mass.