Predictive Response Value of Pre- and Postchemoradiotherapy Variables in Rectal Cancer: An Analysis of Histological Data

Table 5

Predictive value of clinical and pathological characteristics to Mandard response (univariate analysis).

Variables		Bad responders % (Mandard TRG 3–5)	Odds ratio
Distance from anal verge
≤6 cm	86	58.0	1.00	0.017
>6 cm	81	39.5	2.11 (1.14–3.92)
Mitosis number in resected specimen
≤9.5	73	32.9	1.00	<0.001
≥9.6	68	77.9	7.21 (3.40–15.32)
Necrosis grade in resected specimen
Scarce	27	77.8	10.36 (3.76–28.57)	<0.001
Moderate	38	92.1	34.53 (9.76–122.41)	<0.001
Marked	99	25.3	1.00	<0.001
CRM distance
≥2 mm	159	45.9	1.00	0.003
<2 and >1 mm	8	100	2.18 (1.84–2.58)
ypT stage
0-1	38	7.9	1.00	<0.001
2–4	129	60.5	17.84 (5.21–61.09)
ypN stage
0	110	32.7	1.00
1-2	57	78.9	7.71 (3.64–16.34)	<0.001
Pathological stage
0-I	58	15.5	1.00	<0.001
II	58	55.2	6.70 (2.78–16.14)	<0.001
III	51	78.4	19.80 (7.47–52.48)	<0.001
T downstaging
Yes	67	23.9	1.00	<0.001
No	100	65.0	5.92
Pathological TNM downstaging
Yes	96	34.4	1.00	<0.001
No	70	67.1	3.90
Reduction of mitosis number
Yes	83	41.0	1.00	<0.001
No	52	73.1	3.91 (1.84–8.30)
Differentiation grade in resected specimen
0 + 1	52	15.4	1.00	<0.001
2 + 3	115	63.5	9.56