Research Article
Immunohistochemical Investigation of HER/AKT/mTOR Pathway and Cellular Adhesion Molecules in Urothelial Carcinomas
Table 3
Immunoexpression of the markers according to tumors invasiveness.
| | | Muscle-invasive UC (pT2–pT4) | Non-muscle-invasive UC (pTa-pT1) | value |
| | HER2 | | | | | 0 | 4 | 4 | 0.252 | | 1 | 3 | 11 | | 2 | 2 | 9 | | 3 | 4 | 4 |
| | EGFR | | | | | Negative | 10 | 17 | 0.308 | | Positive | 3 | 11 |
| | pAKT | | | | | Nuclear positive | 16 | 8 | 0.790 | | Nuclear negative | 5 | 12 |
| | pAKT | | | | | Cytopl positive | 2 | 9 | 0.315 | | Cytopl negative | 11 | 19 |
| | pmTOR | | | | | Negative | 9 | 10 | 0.045 | | Positive | 4 | 18 |
| | PTEN | | | | | Nuclear positive | 1 | 8 | 0.120 | | Nuclear negative | 12 | 19 | | Missing data | 0 | 1 |
| | PTEN | | | | | Cytopl positive | 3 | 18 | 0.01 | | Cytopl negative | 10 | 9 | | Missing data | 0 | 1 |
| | e-cadherin | | | | | Negative | 4 | 12 | 0.668 | | Positive | 6 | 13 | | Missing data | 3 | 3 |
| | p-cadherin | | | | | Negative | 4 | 16 | 0.307 | | Positive | 5 | 9 | | Missing data | 4 | 3 |
| | b-catenin | | | | | Negative | 2 | 8 | 0.518 | | Positive | 8 | 17 | | Missing data | 3 | 3 |
|
|
Cytopl: cytoplasmic; UC: urothelial carcinomas.
|
