High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach

Figure 3

Immunofluorescent localization galectin-3 in immune and stromal cells of IgG4-RD patients. (a) Immunofluorescent localization of CD123 (green) and galectin 3 (red) in IgG4-RD samples, showing galectin-3 expression in plasmacytoid dendritic cells. (b) Immunofluorescent localization of CD11c (green) and galectin 3 (red) in IgG4-RD samples, showing galectin-3 expression on myeloid dendritic cells. Note the epithelial cells in the duct, on the left (E), positive for galectin-3. (c) CD68 (green) and galectin-3 (red) in IgG4-RD samples, showing galectin-3 expression on macrophages. (d) Galectin-3 (green) and α-smooth muscle actin (red) localization in IgG4-RD samples. Stromal spindle cells were positive for galectin-3, suggesting galectin-3 expression in myofibroblasts. Note the galectin-3 deposition in the stroma. In all experiments, nuclei were stained with DAPI (blue) and images were taken at a magnification of 600x. Gal-3, Galectin-3.

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