Pathology Research International

Molecular Pathology of Gastrointestinal Cancer


Publishing date
01 Apr 2011
Status
Published
Submission deadline
01 Oct 2010

1Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA

2Department of Pathology, University of Pittsburgh School of Medicine, Pittsburg, PA 15213, USA

3Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA

4Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA


Molecular Pathology of Gastrointestinal Cancer

Description

Molecular mechanisms of recent advances in our understanding of gastrointestinal neoplasia have led to the discovery of important molecular alterations that are characteristic of gastrointestinal malignancies, some of which may represent therapeutic targets. Although some changes, such as TP53 tumor suppressor gene mutations, are frequently observed in a variety of different types of cancer, dysplastic precursors, and preneoplastic conditions, an increasing number of different cancers have been shown to harbor relatively specific oncogenic mutations that may be exploited, or manipulated, by novel interventions. As a result, pathologists are increasingly asked to evaluate patient materials for the presence of molecular alterations that may impact patient care.

We invite investigators to contribute original research articles as well as review articles describing the pathologic and molecular features of gastrointestinal malignancies. These manuscripts should stimulate continued efforts to understand the relationships between morphology and molecular alterations, and discuss their roles in emerging treatment strategies for the management of cancers of the gastrointestinal tract. We are particularly interested in articles describing organ-specific molecular testing among gastrointestinal malignancies and the implications of molecular changes on patient treatment.

Potential topics include, but are not limited to:

  • Her-2/neu amplification in adenocarcinomas of the esophagus and stomach
  • The role of EGFR signaling in gastrointestinal carcinogenesis
  • Implications of KRAS mutations for management of patients with colorectal carcinoma
  • Microsatellite instability and gastrointestinal neoplasia
  • DNA methylation and epigenetics
  • Gastrointestinal stromal tumors: Molecular mechanisms and targeted therapies
  • Molecular classification of hepatocellular neoplasms
  • Molecular features of pancreatic ductal neoplasia
  • Inflammatory mediators in the evolution of inflammatory bowel disease: A basis for targeted therapy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/pri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 157073
  • - Review Article

Serrated Polyposis: An Enigmatic Model of Colorectal Cancer Predisposition

Christophe Rosty | Susan Parry | Joanne P. Young
  • Special Issue
  • - Volume 2011
  • - Article ID 902674
  • - Review Article

CpG Island Methylation in Colorectal Cancer: Past, Present and Future

Karen Curtin | Martha L. Slattery | Wade S. Samowitz
  • Special Issue
  • - Volume 2011
  • - Article ID 403929
  • - Review Article

Molecular Pathology of Hepatic Neoplasms: Classification and Clinical Significance

Zenta Walther | Dhanpat Jain
  • Special Issue
  • - Volume 2011
  • - Article ID 620601
  • - Review Article

Molecular Characteristics of Pancreatic Ductal Adenocarcinoma

Niki A. Ottenhof | Roeland F. de Wilde | ... | G. Johan A. Offerhaus
  • Special Issue
  • - Volume 2011
  • - Article ID 219309
  • - Review Article

Impact of KRAS Mutations on Management of Colorectal Carcinoma

Kevin M. Sullivan | Peter S. Kozuch
  • Special Issue
  • - Volume 2011
  • - Article ID 952569
  • - Review Article

Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their Molecular Aspects

Thomas P. Plesec
  • Special Issue
  • - Volume 2011
  • - Article ID 932932
  • - Review Article

EGFR Signaling in Colorectal Carcinoma

Alyssa M. Krasinskas
  • Special Issue
  • - Volume 2011
  • - Article ID 124608
  • - Review Article

MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract

Nicole C. Panarelli | Rhonda K. Yantiss
  • Special Issue
  • - Volume 2011
  • - Article ID 845821
  • - Review Article

Hereditary Diffuse Gastric Cancer: Multidisciplinary Case Report with Review of the Literature

Rebecca Wilcox | Melody Perpich | ... | Kumarasen Cooper
  • Special Issue
  • - Volume 2011
  • - Article ID 193149
  • - Review Article

Molecular Aspects of H. pylori-Related MALT Lymphoma

Scott R. Owens | Lauren B. Smith

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.