Surgical Incision Induces Anxiety-Like Behavior and Amygdala Sensitization: Effects of Morphine and Gabapentin

Figure 2

Effect of hind-paw incision on the p-CREB expression in the CeA of amygdala. Expression of p-CREB in the bilateral CeA of amygdala at 1 hour after sham-operation (a) and (b), at 30 minutes (c) and (d), 1 hour (e) and (f), as well as 3 hours (g) and (h) after surgical incision. The CeA in amygdala are displayed by the labeled circle; (i) and (k) show the quantitative analysis of the OD of p-CREB in the bilateral CeA at indicated times after incision. Bar, 300 m. *$P<.05$ versus the sham-operated control ($n=5$ for each group per indicated time).

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