Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects

Table 1

Colonic myeloperoxidase (MPO) tissue levels 1 week after intracolonic (i-colo) TNBS; effect of concomitant ceftriaxone (CTX).

Treatment (n)	Mean ± SEM (units/mg)
1 wk veh + i-colo veh [22]	0.23±0.05
1 wk CTX + i-colo veh [22]	0.18±0.03
1 wk veh + i-colo TNBS [13]	0.51±0.04^a
1 wk CTX + i-colo TNBS [13]	0.23±0.04^b

One-week CTX treatment (200 mg/Kg/day (302 μmole), ip) attenuated colonic inflammation caused by intracolonic (i-colo) TNBS instillation, as measured by MPO activity. ^a𝑃<0.005 compared to 1-week veh + i-colo veh; ^b𝑃<0.005 compared to 1-week veh + i-colo TNBS).